Discovery of novel hydroxy pyrazole based factor IXa inhibitor

Bioorg Med Chem Lett. 2006 May 15;16(10):2796-9. doi: 10.1016/j.bmcl.2006.01.123. Epub 2006 Feb 17.

Abstract

Synthesis and biological data of a novel selective and efficacious factor IXa inhibitor are described along with its crystal structure in factor VIIa.

MeSH terms

  • Factor IXa / antagonists & inhibitors*
  • Factor IXa / chemistry
  • Humans
  • Models, Molecular
  • Pyrazoles / pharmacology*
  • Serine Proteinase Inhibitors / pharmacology*

Substances

  • Pyrazoles
  • Serine Proteinase Inhibitors
  • Factor IXa